Development and Assessment of a Herbal Cream Enriched with Wild Rue, Winter Cherry, and Turmeric for Skin Disease Treatment

Abstract

Skin disease and skin infections are mostly caused due to physical injuries or bacterial infections. Herbal cream is preferred over other creams due to less side effects of allergic reactions and itching. In the present study, three types of creams (F1, F2, and F3) were prepared by adding different quantities of methanolic extract in dry powder of seeds of wild rue, winter cherry, and the rhizome of turmeric and compared them with standard cream Betadine. The formulations formed were evaluated physically by examining them visually for their color, odor, homogeneity, spreadability, type of smear, emulsion, viscosity and uniformity of weight and skin irritancy of all the three herbal formulations (F1, F2, and F3) and marketed medical betadine cream and noted on 5 different days i.e., 0, 5, 10, 15 and 20 days. The maximum percentage yield was shown by F1 i.e., 42.37% containing 30g turmeric powder and 60 ml methanol. While the lowest i.e., 35.69% was shown by F3 consisting of 50g winter cherry powder and 100 ml methanol. The maximum and minimum antibacterial activity was exhibited by formulation F1 and standard cream at 1.5 mg/ml and 0.5 mg/ml respectively. The creams were oil in water-based and there was no irritation on the skin. This study showed that herbal creams contain natural ingredients that help to improve and satisfy customers because they have fewer adverse effects than synthetic products.